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Acute Kidney Injury

Acute kidney injury (AKI), also known as acute renal failure (ARF), is a sudden episode of kidney failure or kidney damage that happens within a few hours or a few days.

Acute Kidney Injury

  • ⦿ AKI causes a build-up of waste products in your blood and makes it hard for your kidneys to keep the right balance of fluid in your body. AKI can also affect other organs such as the brain, heart, and lungs. Acute kidney injury is common in patients who are in the hospital, in intensive care units, and especially in older adults.

What are the signs and symptoms of acute kidney injury?

Signs and symptoms of acute kidney injury differ depending on the cause and may include:

  • ⦿ Too little urine leaving the body
  • ⦿ Swelling in legs, ankles, and around the eyes
  • ⦿ Fatigue or tiredness
  • ⦿ Shortness of breath
  • ⦿ Confusion
  • ⦿ Nausea
  • ⦿ Seizures or coma in severe cases
  • ⦿ Chest pain or pressure

What causes acute kidney injury?

These diseases and conditions include:

⦿ Low blood pressure (called “hypotension”) or shock
⦿ Blood or fluid loss (such as bleeding, severe diarrhea)
⦿ Heart attack, heart failure, and other conditions leading to decreased heart function
⦿ Organ failure (e.g., heart, liver)
⦿ Overuse of pain medicines called “NSAIDs”, which are used to reduce swelling or relieve pain from headaches, colds, flu, and other ailments. Examples include ibuprofen, ketoprofen, and naproxen.
⦿ Severe allergic reactions
⦿ Burns
⦿ Injury
⦿ Major surgery

Some disease and conditions can damage your kidneys and lead to AKI. Some examples include:

⦿ A type of severe, life-threatening infection called “sepsis”
⦿ A type of cancer called “multiple myeloma”
⦿ A rare condition that causes inflammation and scarring to your blood vessels, making them stiff, weak, and narrow (called “vasculitis”)
⦿ An allergic reaction to certain types of drugs (called “interstitial nephritis”)
⦿ A group of diseases (called “scleroderma”) that affect the connective tissue that supports your internal organs
⦿ Conditions that cause inflammation or damage to the kidney tubules, to the small blood vessels in the kidneys, or to the filtering units in the kidneys (such as “tubular necrosis,” “glomerulonephritis, “vasculitis” or “thrombotic microangiopathy”).

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